ArticleFORMULATION AND EVALUATION OF NANOCARRIER DRUG DELIVERY SYSTEM FOR HYPERPIGMENTATION
Prapti Yadav , *, Narendra Lariya
The study is focused to formulation and evaluation of nanocarrier drug delivery system for Hyperpigmentation. Aspasomes were use as a vesicle for drug delivery and Ascorbyl palmitate were explore as a bilayer vesicle forming material which formed vesicles in combination with cholesterol and Soya Phosphatidylcholine. Aspasomes were prepared by film hydration method followed by sonication in which aqueous drug solution was encapsulated in aqueous regions of bilayer. Differential scanning calorimetric data of Aspasomes dispersion and anhydrous mixtures of ascorbyl palmitate, cholesterol and Soya Phosphatidylcholine confirm the formation of bilayered vesicles with ascorbyl palmitate. The prepared Aspasomes were evaluated for drug entrapment, particle size analysis, scanning electron microscopy, differential scanning calorimetric, transdermal permeation, In vitro (release characteristics), and In vivo. Stability study of aspasomal preparation shown that the formulations were found stable for 60 days. Transdermal permeation of aspasomal preparation was much higher than the other preparations. In vivo experiments revealed that aspasomes decrease the irritation cause by model drug was found in irritation study on rat skin.
Aspasomes, Hyperpigmentation, Differential Scanning Colorimetry, Scanning Electron Microscopy, In vitro and In vivo.