Article

SHORT AND LONG-TERM USE OF CANDESARTAN AND RAMIPRIL IN SPONTANEOUSLY HYPERTENSIVE RATS, LIVER, KIDNEY AND HEART MORPHOLOGY
Maruschak A.V. * ,

Details

Author

Maruschak A.V. *

ISSN

2319-5622

DOI

https://doi.org/10.5281/zenodo.2555307

Published on

Jan 29, 2019

Abstract

Resume: Choosing a method of treating arterial hypertension remains an urgent problem today. For effective therapy, it is necessary to select hypotensive drugs that not only effectively reduce the pressure, but also contribute to the restoration of the structure of tissues sensitive to oscillations of arterial pressure. Purpose: The purpose of this study was to conduct a comparative analysis of the effect of angiotensin 2-candesartan receptor antagonist and angiotensin converting factor ramipril on pathomorphological changes in the myocardium, kidney, and liver in SHR lines that received treatment for 7 days (short) and 21 days (prolonged therapy ) Materials and Methods: The study was conducted on 20 spontaneously hypertensive rats with a mass of 248.0-441.0 g. The rabbit was administered at a dose of 5 mg / kg and candesartan 4 mg / kg, respectively. The period of short-term therapy was 7 days and long-term-21 days. For the evaluation of morphological changes in the heart, kidneys, liver, frozen cross sections were stained using Ramonovsky-Giemsa method. Research Results: The data obtained indicate a more significant effect of candesartan on myocardium and kidney. Ramipril had a negative effect on the renal tubules, increasing the degree of atrophy. Treatment with ramipril and candesartan, especially with longterm use, reduced the hydrophilic swelling of hepatocytes.

Keywords

Candesartan, Ramipril, Hypertensive Rats, Liver, Kidney and Heart Morphology

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