ArticlePrescription Patterns in Anti-Psychotic Medication and Drug Related Problems in Schizophrenia Patients
Cheppalli Vani* , Nikhilesh , Phani Sravya , Jhansi Rani , Abdul Mannan
Objectives: The main objective of the study was prescription patterns of antipsychotics and drug related problems in schizophrenia patients. Methodology: A prospective observational study was conducted in psychiatry (OPD) of tertiary care hospital. The data was collected from OPD for a period of 6 months in 100 cases by using data collection forms Socio-demographic’s, Positive and Negative symptom assessment scale and Glasgow antipsychotic side effect scale used for detection of drug related problems. Statistics was done to the data by using SPSS software. Result: A total of 100 psychiatric patients, female (58%) patients predominated over males patients (42%). Majority of the schizophrenic patients were under age group of 30-40years (43%), positive symptoms (86%) and Paranoid type (75%). Higher number of patients was treated with combination therapy than mono therapy. Among Atypical antipsychotics Risperidone (34%) and Olanzapine (30%) and Typical-antipsychotics Haloperidol (14%) was the most used for patients. The use of Anticholinergic drug like Trihexphenidyl accounts to most of the prescriptions. Mild side effects (81%) were observed like are weight gain, sedation, restlessness, muscle jerky, slower body movements. Some moderate interactions with combination of Olanzapine+Risperidone (increased sedation), Risperidone+Haloperidol (increased QTc interval), and Olanzapine-Quetipine (increases anti dopamergic effects). Conclusion: Our study demonstrates schizophrenia is mostly seen in middle age females. Combination therapy was preferred and Atypical anti-psychotics are used relatively more than Typical’s.
Schizophrenia, Prescription patterns, Antipsychotics, Drug related problems, Positive and Negative Syndrome Scale (PANSS), Glasgow Antipsychotic Side-effect Scale (GASS).