Article

Formulation and Evaluation of Nasal Spray for the Treatment of Migraine Using Aromatherapy
Kumar keshav* , Darshana Gohate , Giri akhand Rachna

Details

Author

Kumar keshav*

ISSN

2319-5622

DOI

doi.org/10.5281/zenodo.3923733

Published on

Jun 30, 2020

Abstract

Objective: the main objective is to develop and formulate a non-toxic, user-friendly, and comfortable intranasal spray formulation of volatile oil for reducing migraine. Materials and Methods: eucalyptus oil, Cween80, Span80, PEG400, nasal spray pumps, reagents and solvents of analytical grade were used. Microemulsions were prepared by water titration method. Nasal spray pumps were evaluated for spray pattern, shot weight and spray content. Invitro study was carried through cellulose acetate membrane respectively. Results: Formulations were developed using (Smix) Cween 80: Span 80 in the ratios of 1:0.25 and 1:0.5, PEG 400 (0.5 gm). These were stable, clear with pH 6.27 and viscosity was 375.85cps. Vp6/100A exhibited the most consistent spray and uniform delivery amongst the tested pumps. The amount of drug diffused was 70% through cellulose acetate membrane within 24hrs. Conclusion: Developed intranasal spray formulations containing eucalyptus oil showed potential to alleviate migraine.

Keywords

Migraine, Eucalyptus oil, Microemulsions, Blood Brain barrier, Intranasal.

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