Article

CATALYTIC SYNTHESIS OF TRIAZOLES AND TETRAZOLES BY COPPER TRIFLATE UNDER MICROWAVE IRRADIATION AND TO EVALUATE THEIR BIOLOGICAL ACTIVITIES
K. Rama Devi* , G. Suryanarayana Murthy , K.S.K Rao Patnaik , D. Ashok , S.Shobha Rani , Raju Bathula ,

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Author

K. Rama Devi*

ISSN

2319-5622

DOI

10.46978/jpr.20.9.8.2

Published on

Aug 05, 2020

Abstract

An efficient synthetic approach of pharmacologically important diversely functionalized compounds (Triazoles and Tetrazoles) through the cycloaddition of Glucals, Azides and nitriles in presence of CuII(OTf) as a catalyst by conventional and microwave methods and to compare the yields. The antibacterial activity of the triazoles and tetrazole were tested by serial dilution method taking drug at a concentration of 150 mg/ml. The anti-fungal activies of the triazoles and tetrazole were tested by agar diffusion method (cup-plate method) taking drug at a concentration of 100 mg/ml and 150 mg/ml against five fungi (C.albicans, C.rugosa, S.cerevisiae, A.flavus and A.niger).

Keywords

Cycloaddition, CuII(OTf), antibacterial activity & anti-fungal activity.

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