ArticleCannabinoid Receptor 1: Allosteric Modulation and its Therapeutic Potential
Debra A. Kendall* , Jonathan Choiniere ,
Debra A. Kendall*
The cannabinoid receptors and endocannabinoid system play a role in many physiological processes which makes the cannabinoid receptor 1 a good target for therapies to a wide range of pathologies such as addiction, obesity, pain, depression, anxiety, and neurodegenerative disorders. Despite all of the therapeutic potential of creating cannabinoid receptor specific drugs, development of such medications has been difficult due to psychoactive side effects that are linked to agonist and antagonist ligands. This review focuses on describing cannabinoid receptor 1, its therapeutic potential, and exploring the possibility of using allosteric modulator compounds as a way to maximize medicinal benefit while limiting psychoactive side effects.
cannabinoid receptor 1; allosteric modulator; G protein coupled receptor; ligands