ArticleEvaluating Polyherbal Compound – Bharangyadi for Anti-Platelet aggregating effect and Steroidogenesis activity
Kajaria Divya , Tripathi. J.S , Tiwari. S.K.
Bharangyadi is a self experienced indigenous polyherbal Ayurvedic preparation use for the management of bronchial as thma. Desire for searching the probable mode of action of this drug, following study was carried out. Allergy and inflammation are two closely related as well as mutually dependent factors. Inflammation is characterized by interactions among platelets, leukocytes, and ECs. These interactions tri gger autocrine and paracrine activation processes that lead to leukocyte recruitment into the vascular wall and Platelet-induced chronic inflammatory processes. Anti-Platelet aggregating effect of drug indirectly signifies anti-inflammatory activity.Antigen antibodies reaction, disruption of mas t cell and liberation of inflammatory mediators are initiative in pathology of asthma. Thus in present trial anti-platelet aggregation and effect of drug on adrenal gland and s pleen is use to assess the efficacy of drug in asthma. Study reveals negative result in both platelet aggregation inhibition and adrenal gland stimulation.
Bharangyadi polyherbal compound, complementary medicine, anti-platelet aggregation, steroidogenesis activity.