Article

Synthesis and Screening method of New Isatin Derivatives
V. Rajini priya , M. Aruna Devi* , N. Raghunandan and J. Venkateshwar Rao

Details

Author

V. Rajini priya

ISSN

2319-5622

DOI

4

Published on

Nov 29, 2013

Abstract

2-[(1H-benzimidazol-2-ylmethyl) sulfanyl]-N1 -[2-oxo-1,2-dihydro-3H-indol-3-ylidene] acetohydrazides, which were prepared by treatment of 2-chloro-N1 -[2-oxo-1,2-dihydro-3H-indol-3-ylidene] acetohydrazides with 1H-benzimidazole-2-ylmethanethiol in good yields. The structures of all componmds were confirmed by IR, 1H NMR, Mass spectral analysis. All the compounds were screened for their anti-inflammatory activities. Out of these compounds, compound VIIc (5-CH3) and VIId (7-CH3) exhibited maximum activity with percentage of inhibition of 68.56 and 61.41.All the text compounds showed mild to moderate anti-inflammatory activity

Keywords

Isatin derivatives, Anti-inflammatory activity

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