ArticleStructure Elucidation and Biological Activities of 1-(3-bromo-5-methylphenyl)-1H-indole from Marine Streptomyces sp LCJ85
Gunasekaran Mohanraj , Thangavel Sekar*, Subramani Karthikeyan
The marine Streptomyces sp LCJ85 isolated from sediments of Bay of Bengal produced biologically active compound 1-(3-bromo-5- methylphenyl)-1H-indole. The compound inhibited the human bacterial pathogens and with a effective mic value of 1.56 μg/mL against the Staphylococcus aureus. The DPPH assay showed good free radical scavenging by the compound with a IC50 value of 44 µg/mL. The HepG2 cells experienced a significant decrease in viability at very low oncentrations of 1-(3-bromo-5-methylphenyl)-1H-indole with an eventual decline at the high concentrations of indole compound in the cytotoxicity assay. The IC50 values of compound against the HepG2 cells was found to be 192 µg/mL. The results from these study proves that the marine actinomycete Streptomyces sp LCJ85 will be a effective source of biologically important secondary metabolites.
Streptomyces, Resazurin, 1, 1-diphenyl-2-picryl hydrazyl, Free radical.