ArticleA Review updated on Mucoadhesive
Akanksha Chandra* , Rajesh Kumar Soni, Upendra Sharma, S.K. Jain
The idea of developing Mucoadhesive polymers for drug delivery has been introduced into the pharmaceutical product development for more than 40 years ago and nowadays it has been subjected as a promising strategy to improve the residence time and the specific localization of drug delivery systems on various mucus membranes. Mucoadhesive drug delivery systems based on adhesion to biological surfaces that are covered by mucus. Mucoadhesion can be defined as a state in which two components, of which one is of biological origin are held together for extended periods of time by the help of interfacial forces mucoadhesion is the attachment of the drug along with a suitable c arrier to the mucous membrane. Mucoadhesion is a complex phenomenon which involves wetting, adsorption and inte rpenetration of polymer chains. The Mucoadhesive polymers can be categorized into two broad categories, materials which undergo matrix formation or hydrogel formation by either a water swell able material or a water soluble material. Mucoadhesive drug delivery systems is one of the most important novel drug delivery systems with it various advantages and it has a lot of potential in formulating dosage forms for various chronic diseases. Th e Mucoadhesive interaction is explained in relation to the structural characteristics of mucosal tissues and the theories and properties of the polymers. The success and degree of mucoadhesion bonding is influenced by various polymer-based properties. In this abstracts for buccal route of administration of Mucoadhesive films are retentive dosage forms and release drug directly into a biological substrate. This review will consider the literature that describes the manufacture and characterization of Mucoadhesive buccal film.
Mucoadhesive, Drug Delivery System, Labetalol hydrochloride